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Ph.D., Chemical Engineering

California Institute of Technology
Pasadena, CA

• Thesis (Defended 6/20/24): Global Analysis of Protein Synthesis and Degradation in Escherichia coli

B.S., Chemical Engineering

University of Florida

• Minor: Biomolecular Engineering

Postdoctoral Scholar, Chemical Engineering
Ph.D. Candidate, Chemical Engineering

California Institute of Technology, Pasadena, CA

• Discovered global regulatory roles of protein degradation by combining chemoproteomic analysis, linear modeling, text mining, and machine learning to identify 186 novel protease substrate candidates in Escherichia coli.
• Developed a predictive machine learning model for in vivo protein stability in E. coli, achieving 87.5% accuracy in the experimental validation of 8 substrates.
• Engineered and deployed an open-source interactive application for filtering, normalization, differential expression analysis, and pathway enrichment analysis of mass spectrometry–based proteomics data. (repository) (publication)
• Identified DNA repair factors recruited to colibactin-induced DNA interstrand cross-links in Xenopus egg extracts via differential expression analysis and time-series clustering of chromatin mass spectrometry data. (preprint)

Bioinformatics Co-op

EMD Serono, Department of Translational Medicine and Global Clinical Development, Remote

• Developed Shiny application for visualizing cell type—specific transcript abundance, identifying differentially expressed genes, and conducting gene set enrichment analysis in clinical samples across autoimmune disease states.
• Established pipeline and Shiny application for the real-time analysis of text mining data from PubMed to identify genes, pathways, and diseases of therapeutic interest through information-theoretic and statistical approaches.

NSF REU Fellow

Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston MA

• Investigated the effects of photocrosslinking on ex vivo tissue biomechanics via cyclic uniaxial tensile testing.

NSF REU Fellow

Johns Hopkins University School of Medicine, Department of Radiation Oncology, Baltimore, MD

• Evaluated the anti-tumor immune response generated by magnetic nanoparticle hyperthermia and ionizing radiation treatments in a mouse model for cancer.

Undergraduate Research Assistant

University of Florida, Department of Chemistry, Gainesville, FL

• Developed an amphiphilic and pH-responsive copolymer for site-specific drug delivery in plants by functionalizing polysuccinimide with hydrophilic molecules.

tidyproteomics-interactive

• A Shiny application for interactively working with tidyproteomics, an R package for processing protein- and peptide-level data and conducting statistical analysis.

• Center for Environmental Microbial Interactions (CEMI) Pilot Grant, California Institute of Technology

• CEMI Fellow, California Institute of Technology

• NSF Graduate Research Fellowship, California Institute of Technology

• Yao Su Student Research Prize, HST Summer Institute
• NSF REU Fellowship, Harvard-MIT Division of Health Sciences and Technology (HST)
• Collins Engineering Scholarship, University of Florida

• NSF REU Fellowship, Johns Hopkins University Institute for NanoBioTechnology (INBT)

• University Scholars Program, University of Florida